Adolescent cannabinoid exposure induces a persistent sub-cortical hyper-dopaminergic state and associated molecular adaptations in the prefrontal cortex

1/13/16–Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol (THC), treatment the psychoactive component in marijuana, increases the risk of developing schizophrenia-related symptoms in early adulthood. Study findings demonstrate a profound dissociation in relative risk profiles for adolescent versus adulthood exposure to THC in terms of neuronal, behavioral, and molecular markers resembling neuropsychiatric pathology. Read