Tag: JAMA Network

12/23/20--In this study, both cannabidiol dosages were equally efficacious in reducing tuberous sclerosis complex–associated seizures compared with placebo, but the smaller dosage led to fewer adverse events. Read

12/23/20--This study aiming to estimate the prevalence of and factors associated with driving after using marijuana (DAUM) among US teenaged drivers found that almost half (48.8%) of teen drivers who currently use marijuana reported DAUM, which is 17% higher than the rate found in a study of first-year college students in 2012. The study also found that the prevalence of DAUM (12.7%) was more than double the prevalence of drinking and driving (5.0%), perhaps reflecting teens’ perception that DAUM is less dangerous and more acceptable than driving after using alcohol. Read

12/21/20--This study provides 2018-2019 prevalence estimates of and 1976-2019 trends in solitary alcohol and marijuana use among all 12th grade students and those who used alcohol and marijuana in the past 12 months, separated by sex. Read

12/3/20--In a national, online, cross-sectional survey study of 2167 youth and young adults using e-cigarettes, 1198 respondents reported changing their amount of e-cigarette use, with 810 reducing or quitting e-cigarette use. During the COVID-19 pandemic, youth e-cigarette users reported changes in e-cigarette use, point-of-purchase, and ability to purchase e-cigarettes without age verification. Read

12/17/20-- This cohort study found differences between female and male youths in sociodemographic and clinical characteristics and incidence of NFOD. Although female and male youths who experience overdose appear to have different risk factors, many of these risk factors may be amenable to early detection through screening and intervention. Read

12/2/20--In this cross-sectional study of 1,297,362 US adolescents surveyed between 2011 and 2019, past 30-day and daily use of cigarettes and smokeless tobacco decreased more rapidly since 2012 as e-cigarette use began to increase. Smoking and smokeless tobacco use reached historically low levels among adolescents in the US. Read

12/1/20--According to a JAMA article, little is known about how people who consume CBD fare behind the wheel. Much of the research into cannabis’s effect on driving performance has focused on the whole plant and its other main cannabinoid, tetrahydrocannabinol, or THC, which produces euphoria. Read

12/1/20--n this cross-sectional, US population-based study, cancer in AYAs was shown to have a unique epidemiological pattern and is a growing health concern, with many cancer subtypes having increased in incidence from 1973 to 2015. Continued research on AYA cancers is important to understanding and addressing the distinct health concerns of this population. Read

10/6/20--In this repeated cross-sectional study including 71,756 young adults aged 22 to 23 years, the proportion of ever smokers who initiated cigarette smoking in early adulthood more than doubled between 2002 and 2018, and the proportion of daily cigarette smokers who transitioned to daily smoking in early adulthood also increased from 38.7% in 2002 to 55.9% in 2018. Read

10/6/20--This study by Barrington-Trimis et al used data from the National Survey on Drug Use and Health to examine the proportion of young adult cigarette smokers (aged 22-23 years) who initiated smoking in young adulthood from 2002 to 2018. Barrington-Trimis and colleagues found that during this period with population-level declines in cigarette smoking among youth and young adults, the average age of smoking initiation and the proportion of new initiates and daily smokers who were young adults increased. Read

10/27/20--People with substance use disorder (SUD), particularly those with opioid use disorder (OUD) and Black individuals, are at an increased risk of coronavirus disease 2019 (COVID-19), according to a recent study coauthored by Nora Volkow, MD, director of the National Institute on Drug Abuse (NIDA). Read

10/27/20--From 2008 to 2017, the rate of emergency department (ED) visits related to suicidal ideation or suicide attempt increased among all age groups 5 years or older, according to a recent report from the Agency for Healthcare Research and Quality (AHRQ). Suicide, which ranks among the top 10 US causes of death, is a growing US public health problem, the report noted. The suicide rate in 2017 was 14 per 100 000 population, representing more than 47 000 deaths. Read

10/27/20--According to the latest National Survey on Drug Use and Health, compiled by the Substance Abuse and Mental Health Services Administration, among people aged 12 years or older in 2019, 60.1% reported having used a substance during the past month. Yet, the proportion of adolescents aged 12 to 17 years who reported consuming alcohol in the past month declined from 17.6% in 2002 to 9.4% in 2019. During that period, past-month cigarette use decreased from 26% to 16.7% among people aged 12 years or older. Read

10/20/20--According to the 2020 National Youth Tobacco Survey, conducted by researchers at the FDA and the Centers for Disease Control and Prevention, youth e-cigarette use declined by a third after 2 years of increases. It showed that 19.6% of high school students (3.02 million) reported e-cigarette use, down from 27.5% (4.11 million) in 2019. Among middle school students, 4.7% (550 000) reported e-cigarette use compared with 10.5% (1.24 million) in 2019. Read

10/27/20--People with substance use disorder (SUD), particularly those with opioid use disorder (OUD) and Black individuals, are at an increased risk of coronavirus disease 2019 (COVID-19), according to a recent study coauthored by Nora Volkow, MD, director of the National Institute on Drug Abuse (NIDA). Volkow and her coauthors conducted a case-control study of deidentified electronic health records for nearly 73.1 million unique patients, including 12 030 with diagnosed COVID-19. Read

10/27/20--Among people aged 12 years or older in 2019, 60.1% reported having used a substance during the past month, according to the latest National Survey on Drug Use and Health, compiled by the Substance Abuse and Mental Health Services Administration. The most commonly reported substance used in the past month was alcohol, consumed by 50.8% of survey respondents, followed by tobacco, used by 21.1%. In addition, 13% used an illicit drug. Read

10/27/20--From 2008 to 2017, the rate of emergency department (ED) visits related to suicidal ideation or suicide attempt increased among all age groups 5 years or older, according to a recent report from the Agency for Healthcare Research and Quality (AHRQ). Overall, males were more likely than females to present to an ED because of suicidal ideation or a suicide attempt, although females aged 10 to 19 years had higher rates of ED visits for suicidal ideation or suicide attempt, with the highest rate of such visits among females aged 15 to 19 years  Read

10/6/20--In this cohort study, the prevalence and type of nicotine vaping and cannabis vaping developmental trajectories from late adolescence to young adulthood were similar. Polysubstance vaping was common from late adolescence to young adulthood, particularly among those reporting more frequent vaping use. The findings suggest that public health policy and clinical interventions should address polysubstance vaping in both adolescence and young adulthood. Read

10/12/20--The findings of this study suggest that US colleges and communities should create and maintain supportive resources for young adults as the substance use landscape changes, specifically as alcohol abstinence, marijuana use, and co-use increase. Interventions for polysubstance use, alcohol use disorder, and marijuana use disorder may provide valuable opportunities for clinicians to screen for prescription drug misuse. Read

9/15/20--Epidiolex, is the only FDA-approved drug with CBD as an active ingredient, was approved to treat seizures associated with tuberous sclerosis complex (TSC) in patients aged 1 year or older. TSC is a genetic disease that causes benign tumors to grow throughout the body. Read

8/7/20--According to a study, menthol cigarette market share increased by nearly 10 percentage points from 2000 to 2018. Overall, cigarette consumption declined 46.0% from 2000 (435.6 billion cigarettes) to 2018 (235.3 billion cigarettes), but the decline was greater among nonmenthol cigarettes (52.9%; 322.8 billion to 152.0 billion cigarettes) than for menthol cigarettes (26.1%; 112.8 billion to 83.3 billion cigarettes in 2018). Read

9/11/20--This serial cross-sectional study using US mortality data from 2000 to 2017, including 1,446 ,177 drug poisoning, suicide, and alcohol-induced premature deaths found that demographic characteristics and geographic patterns varied by cause of death, suggesting that increasing death rates from these causes were not concentrated in 1 group or region. Specialized interventions tailored for the underlying drivers of each cause of death are urgently needed.. Read

8/7/20--This serial cross-sectional study estimates menthol and nonmenthol cigarette consumption from 2000 to 2018 with a previously used approach. Results indicate that the large decline in cigarette consumption in the US over the last 2 decades is overwhelmingly attributed to nonmenthol cigarettes, and this trend is more pronounced since the signing of the TCA. Read

7/29/20--Until very recently, no companies would manufacture medical-grade psychedelics, which made getting regulatory approval for clinical research—especially clinical trials—very difficult and in some countries (eg, Germany) impossible. Read

7/20/20--Studies have indicated that cartoons are an effective strategy in increasing product recognition and susceptibility to use e-cigarettes. Recently, the US Food and Drug Administration announced it is prioritizing enforcement against e-cigarette companies that use marketing likely to promote youth use. This study aimed to determine if companies were using cartoon-based strategies to market and promote e-cigarette–associated products in 2019 on Instagram. Read

7/17/20-- This randomized clinical trial found that, compared with vaporized placebo, vaporized cannabis did not statistically significantly reduce pain and associated symptoms, except interference in mood, in patients with SCD with chronic pain. Read

7/14/20--According to this study, state-level policies designating opioid use disorder (OUD) as a qualifying condition for medical cannabis were associated with more dispensaries claiming cannabis can treat OUD. Future studies linking dispensary advertisements to health outcomes in people with OUD (eg, use of MOUDs, overdose mortality) are warranted, as are investigations into advertising that addresses other conditions with major morbidity and mortality consequences. Read

6/22/20--The 2 studies evaluating the association of recreational cannabis laws with motor vehicle crash deaths by Santaella-Tenorio et al and Kamer et al in this issue of JAMA Internal Medicine contribute to an emerging body of research necessary to inform policy on cannabis and impaired driving. Both studies use natural experiments in policy implementation to provide a high-level perspective of how legalization of recreational cannabis use may affect motor vehicle crash deaths in the population. Read

6/22/20--Using a synthetic control approach, this ecological study found that recreational cannabis laws were associated with increases in traffic fatalities in Colorado (mean of 75 excess fatalities per year) but not in Washington State. These findings suggest that unintended effects of recreational cannabis laws can be heterogeneous and may be specific to variations in how these laws are implemented (eg, density of recreational cannabis stores). Read

6/22/20--Researchers have not yet conclusively determined if a state’s legalizing recreational marijuana is associated with traffic fatality rates. Two early studies reported no significant change in roadway deaths following legalization in Colorado and Washington, whereas a study including Oregon reported a temporary increase. A more recent study, including 2017 data, found a statistically significant increase in fatal crashes only after commercial stores opened, suggesting that the effect of legalization may take more time to observe. Read

6/19/20--The aim of this cross-sectional study is to assess the extent to which potential best practices, including those from tobacco control, were incorporated into state and local marijuana policies in California. Results indicate that all 539 California cities and counties found that jurisdictions differed widely in how they regulated marijuana and that key public health recommendations and lessons from tobacco control have generally not been adopted, although local innovation is emerging. Read

6/5/20--In this study, risk of cigarette smoking relapse among former cigarette smokers was higher among those who used electronic nicotine delivery systems or other tobacco products compared with those who did not. Furthermore, for clinicians treating former smokers who have successfully quit all nicotine products, the implications are that use of ENDS products should be discouraged, just as use of all other tobacco products is discouraged. Read

6/5/20--In this study, lower socioeconomic position was associated with higher rates of e-cigarette use among those who quit smoking after e-cigarettes became widely available, likely reflecting continued use of e-cigarettes as a long-term cessation aid among individuals with lower socioeconomic positions. Read

6/5/20--In this cohort study with 17, 929 participants, multivariable analyses of nationally representative, longitudinal survey data evaluated differences in smoking initiation and cessation subsequent to vaping uptake among those who used flavored vs unflavored e-cigarettes, separately by age group. Results indicate that adults who began vaping nontobacco-flavored e-cigarettes were more likely to quit smoking than those who vaped tobacco flavors. More research is needed to establish the relationship between e-cigarette flavors and smoking and to guide related policy. Read

5/26/20--The study was designed to review the benefits and harms of interventions to prevent illicit and nonmedical drug use in children, adolescents, and young adults to inform the US Preventive Services Task Force. Evidence concludes that behavioral counseling interventions to prevent initiation of illicit and nonmedical drug use among adolescents and young adults was inconsistent and imprecise, with some interventions associated with reduction in use and others associated with no benefit or increased use. Read

5/26/20--To update its 2014 recommendation, the USPSTF commissioned a review of the evidence on the potential benefits and harms of interventions to prevent illicit drug use in children, adolescents, and young adults. It has been concluded that the current evidence is insufficient to assess the balance of benefits and harms of primary care–based behavioral counseling interventions to prevent illicit drug use, including nonmedical use of prescription drugs, in children, adolescents, and young adults. Read

6/10/20--This study provides information about the association of pharmacological and neurobehavioral outcomes with legal market cannabis. Short-term use of concentrates was associated with higher levels of THC exposure. Across forms of cannabis and potencies, users’ domains of verbal memory and proprioception-focused postural stability were primarily associated with THC administration. Read

5/27/20--A study designed to explore the association between cannabis potency and substance use and mental health outcomes, accounting for preceding mental health and frequency of cannabis use suggests that the use of high-potency cannabis is associated with mental health and addiction. Limiting the availability of high-potency cannabis may be associated with a reduction in the number of individuals who develop cannabis use disorders, the prevention of cannabis use from escalating to a regular behavior, and a reduction in the risk of mental health disorders. Read

5/26/20--Based on a study designed to review the benefits and harms of interventions to prevent illicit and nonmedical drug use in children, adolescents, and young adults to inform the US Preventive Services Task Force, evidence for behavioral counseling interventions to prevent initiation of illicit and nonmedical drug use among adolescents and young adults was inconsistent and imprecise, with some interventions associated with reduction in use and others associated with no benefit or increased use. Health, social, and legal outcomes were sparsely reported, and few showed improvements. Read

5/26/20--Illicit drug use is associated with many negative health, social, and economic consequences and is a significant contributor to 3 of the leading causes of death among young persons (aged 10-24 years): unintentional injuries including motor vehicle crashes, suicide, and homicide. However, the USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of primary care–based behavioral counseling interventions to prevent illicit drug use, including nonmedical use of prescription drugs, in children, adolescents, and young adults. Read

4/28/20--In this issue of JAMA, the US Preventive Services Task Force (USPSTF) presents updated recommendations on prevention and cessation of tobacco use among children and adolescents seen in primary care settings. The USPSTF recommends education and brief counseling with a clinician to prevent initiation of tobacco use. The USPSTF also concludes that evidence is insufficient to assess the balance of benefits and harms of primary care–feasible interventions for the cessation of tobacco use among school-aged children and adolescents. Read

5/4/20--The prevalence of vaping increased between 2018 and 2019 within all 3 countries, but was substantially more prevalent in Canada and the US compared with England. Vaping was substantially higher among individuals who reported smoking than other respondents in all 3 countries, although increases between 2017 and 2019 were observed across all subgroups for most measures of vaping in the US and Canada including among those who reported never smoking. Read

5/4/20--The use of e-cigarettes among youths has reached epidemic proportions in the United States. Juul is the most popular brand of e-cigarettes among youth, and it has been criticized for marketing that targets youths. Concerns of serious short-term and long-term health outcomes from e-cigarette use have led to actions from the US Food and Drug Administration, states, and municipalities to ban or restrict the sale of e-cigarettes. Read

4/28/20--Tobacco use is the leading cause of preventable death in the US. An estimated annual 480,000 deaths are attributable to tobacco use in adults, including from secondhand smoke. The USPSTF commissioned a review of the evidence on the benefits and harms of primary care interventions for tobacco use prevention and cessation in children and adolescents. The current systematic review newly included e-cigarettes as a tobacco product. Read

4/22/20--In this cross-sectional study based on national representative data of 1,222,419 suicidal acts, increased suicide rates were associated with an increase in both incidence rates and lethality of suicidal acts from 2006 to 2015. In subgroup analyses, incidence of suicidal acts increased among female persons, adolescents, and older adults aged 65 to 74 years, whereas suicidal acts became more lethal among both sexes and persons aged 20 to 64 years. Read

4/6/20--There is growing evidence associating adolescent marijuana use with developmental and societal consequences. Prevalence and trends from 2015 to 2018 in noncombustible marijuana use and differences by use frequency and sociodemographic characteristics have been documented. Vaping has increased rapidly among adolescents, and Regional data suggest boys vape more than girls, but there are conflicting reports of sex differences in edible use, and differences across modes of use for race/ethnicity, and socioeconomic status (SES). Read

2/21/20--A serial cross-sectional study using US mortality data from 2000 to 2016 found large increases in alcohol-induced death rates across age and racial/ethnic subgroups of the US population, which have accelerated over recent years. Large increases in alcohol-induced deaths among younger age groups may be associated with future increases in alcohol-related disease. Read

3/2/20--Adjunctive cannabidiol at doses of 10 and 20 mg/kg/d led to similar clinically relevant reductions in convulsive seizure frequency with a better safety and tolerability profile for the 10-mg/kg/d dose in children with treatment-resistant Dravet syndrome. Dose increases of cannabidiol to greater than 10 mg/kg/d should be tailored to individual efficacy and safety. Read

2/12/20--In a survey study of 4183 respondents examining factors associated with use of electronic cigarettes (e-cigarettes), including JUUL, among high school students, inclusion of a JUUL use measure produced higher estimates of current use than assessing the use of e-cigarettes or JUUL alone, and 88.8% of youth reported using the JUUL brand. In addition, current use of other tobacco products, endorsing a tobacco brand on social media, having tobacco-branded merchandise, having close friends who used JUUL, and seeing JUUL used on school grounds were significantly associated with current and frequent e-cigarette use, inclusive of JUUL. Read

2/11/20--Medical cannabis refers to preparations of the cannabis plant that patients use to treat medical conditions, and it has been used for medicinal purposes for thousands of years by many civilizations. As of January 2020, 33 states and the District of Columbia had put laws into place so physicians can certify the use of “medical marijuana,” or medical cannabis, for debilitating medical conditions—although cannabis remains illegal federally. Read

2/11/20--The JAMA Internal Medicine Patient Page outlines pertinent details about medical marijuana, it's use, the dangers, and how it's regulated in the United States. Read 

1/16/20--As published in JAMA Oncology, a thorough review by the US National Academies of Sciences, Engineering, and Medicine found moderate evidence of no statistical association between cannabis use and the development of lung and head and neck cancers. Furthermore, limited evidence of a statistical association was found between cannabis use and the development of nonseminomatous testicular carcinomas without good support for a causative effect. Read

11/5/19--In a cross-sectional survey conducted in 2019 that included 19,018 participants to examine the estimated frequency of the current (past 30-day) use of e-cigarettes among US high school and middle school students in 2019, the findings indicate that the prevalence of self-reported current e-cigarette use was high among US high school and middle school students. Read

11/20/19--Although the CBD market has exploded in recent months, with products ranging from bath salts to coffee and tea to maple bacon–flavored dog biscuits, research suggests that many actually do not contain CBD. And the compound’s murky status raises a host of questions: Is it safe? Is it effective? Is it legal? Is it a dietary supplement or a drug? Read

11/13/19--Findings in a multilevel, difference-in-difference survey study with 505 796 respondents comparing marijuana use before and after the legalization of recreational marijuana in the United States, revealed that the proportion of respondents aged 12 to 17 years reporting cannabis use disorder increased from 2.18% to 2.72%, while the proportion of respondents 26 years or older reporting frequent marijuana use increased from 2.13% to 2.62% and those with cannabis use disorder, from 0.90% to 1.23%. Read

11/1/19--The opioid crisis has accounted for 770 000 deaths in the United States over the past 20 years, and this crisis has contributed to the decline in US overall life expectancy for 3 consecutive years. Responsibility for holding corporations accountable for their role in the opioid epidemic—and ensuring they contribute to solutions—falls primarily to state attorneys general who are responsible for protecting the public and can act individually or as a group through lawsuits or negotiations when public health is threatened. Read

9/20/19--This survey study using data from 169,036 participants in the 2016 and 2017 Behavioral Risk Factor Surveillance System surveys found that, compared with adults without medical conditions, adults with medical conditions had a significantly higher prevalence of current and daily marijuana use, were more likely to report using marijuana for medical reasons, and were less likely to report using marijuana for recreational purposes. Read

8/8/19--In a systematic review of 6 human studies and 13 basic science and animal studies, cannabis inhalation was associated with dark vocal folds on laryngoscopy as well as respiratory symptoms and negative lung function changes attributable to degradation byproducts generated during smoke exposure, especially in large doses. Read

8/9/19--As of August 2019, 33 states and the District of Columbia have initiated policies allowing the use of cannabis or cannabinoids for the management of specific medical conditions. Yet, insufficient evidence exists for the use of medical cannabis for most conditions for which its use is advocated. Despite the lack of evidence, various US state governments have recommended cannabis for the management of more than 50 medical conditions. Read

11/30/18--Significant, sometimes adverse, drug effects can occur at relatively low THC doses in infrequent marijuana users, and accordingly this data should be considered with regard to regulation of retail marijuana products and education for individuals initiating marijuana use. Read