Home Tags NIH

Tag: NIH

Medical cannabis authorization and the risk of cardiovascular events: a longitude cohort study

9/10/21--Cannabis is increasingly used for therapeutic purpose. However, its safety profile is not well known. This study assessed the risk of cardiovascular-related emergency department (ED) visit and hospitalization in adult patients authorized to use medical cannabis in Ontario, Canada from 2014 to 2017. Read

Marijuana use at historic high among college-aged adults in 2020

9/8/21--Marijuana use continued to rise among college students over the past five years and remained at historically high levels among same-aged peers who are not in college in 2020, according to survey results from the 2020 Monitoring the Future (MTF) panel study. This represents the highest levels of marijuana use recorded since the 1980s. Read

Use of electric cigarettes as a predictor of cannabis experimentation: A longitudinal study among German youth

8/12/21--This study aimed to investigate whether e-cigarette use longitudinally predicts experimentation with cannabis, and results indicate that e-cigarette use is associated with a subsequent initiation of cannabis use. This association seems to be stronger for youth who have a lower risk for substance use in general. Future studies need to investigate whether this is only true for experimental or also more frequent cannabis use. Read

Words matter: language can reduce mental health and addiction stigma, NIH leaders say

7/18/21--Leaders from the National Institutes of Health address how using appropriate language to describe mental illness and addiction can help to reduce stigma and improve how people with these conditions are treated in health care settings and throughout society. Read

Addiction treatment in the postpartum period: an opportunity for evidence-based personalized medicine

7/8/21--In this article, the existing evidence as well as highlight opportunities for both clinicians and researchers to advance the integration of tailored approaches for postpartum women into personalized SUD medical and behavioral treatments are reviewed. Read

Pediatric cannabis intoxication trends in the pre and post-legalization era

6/17/21--Results from a retrospective cohort study of children 0-18 years who presented to a pediatric ED between January 1, 2008 and December 31, 2019 with cannabis intoxication indicate that the recreational cannabis legalization in Canada is associated with increased rates of severe intoxications in children. Edible ingestion is a strong predictor of ICU admission in the pediatric population. Read

Association of cannabis use during adolescence with neurodevelopment

6/16/21--Results of a study designed to examine the degree to which magnetic resonance (MR) imaging-assessed cerebral cortical thickness development is associated with cannabis use in a longitudinal sample of adolescents suggest that cannabis use during adolescence is associated with altered neurodevelopment, particularly in cortices rich in cannabinoid 1 receptors and undergoing the greatest age-related thickness change in middle to late adolescence. Read

Cannabinoids, Phenolics, Terpenes and Alkaloids of cannabis

5/8/21--This review discusses the chemistry of the cannabinoids and major non-cannabinoid constituents (terpenes, non-cannabinoid phenolics, and alkaloids) with special emphasis on their chemical structures, methods of isolation, and identification. Read

Cannabis use and clinical outcome in people with first-episode schizophrenia spectrum disorders over 24 months of treatment

5/19/21--In this longitudinal study, the influence of cannabis use on baseline symptom severity and treatment outcomes in 98 patients with first-episode schizophrenia spectrum disorders treated with a long acting injectable antipsychotic over 24 months was explored. Using mixed models for repeated measures, we compared visit-wise changes in psychopathology, social and occupational functioning and quality of life between recent/current cannabis users (n=45) and non-users (n=53) were compared. Read

A cascade of care for alcohol use disorder: using 2015-2018 national survey and health date to identify gaps in care

5/19/21--For this study, a cascade of care framework was used to understand gaps in care between diagnosis and treatment for persons with AUD. Persons with AUD utilize health care at high rates and are frequently screened about alcohol use, but few receive treatment. Health care settings-particularly primary care settings-represent a prime opportunity to implement pharmacologic treatment for AUD to improve outcomes in this high-risk population. Read

A cascade of care for alcohol use disorder: Using 2015-2018 national survey on drug use and health data identify gaps in care

5/19/21--According to a study using a cascade of care framework to understand gaps in care between diagnosis and treatment for persons with AUD, persons with AUD utilize health care at high rates and are frequently screened about alcohol use, but few receive treatment. Health care settings-particularly primary care settings-represent a prime opportunity to implement pharmacologic treatment for AUD to improve outcomes in this high-risk population. Read

The associations between prenatal cannabis use disorder and neonatal outcomes

4/22/21--Cannabis use disorder (CUD) during pregnancy has increased dramatically in the United States (US). This study examined the associations between prenatal CUD and adverse neonatal outcomes and heterogeneities in the associations by mothers' tobacco use status and race/ethnicity. Read

Association between adolescent cannabis use and young-adult functioning in three longitudinal twin studies

4/6/21--The purpose of the present study was thus to examine associations between prospectively assessed adolescent cannabis use and young-adult outcomes (psychiatric, cognitive, and socioeconomic) in three longitudinal studies of twins (n = 3,762). findings thus suggest that cannabis use in adolescence has potentially causal, deleterious effects on adolescent academic functioning and young-adult socioeconomic outcomes despite little evidence suggesting a strong, causal influence on adult mental health or cognitive ability. Read

Prevalence and correlates of driving under the influence of cannabis in the U.S.

3/13/21--In 2020, public-use data from the National Survey on Drug Use and Health were examined, using an analytic sample of 128,205 adults interviewed between 2016 and 2018. Findings from a study suggest that prevention efforts should focus on frequent and problem cannabis users and should include content related to other illicit drug use and other drug-impaired driving. Read

Trends in cannabis use among adults with children in the home in the United States, 2004-2017

3/17/21--According to this study, among adults with children living in the home, cannabis use appears to be more common in US states with legalized cannabis use compared with states with no legal cannabis use. Recreational legalization appears to increase use among adults with children in the home broadly across nearly all sociodemographic groups, whereas the effect of legalization for medical use is heterogeneous by age and socioeconomic status. Read

A geospatiotemporal and casual inference epidemiological exploration of substance and cannabinoid exposure as drivers of rising US pediatric cancer rates

2/25/21--Data from this study confirms a close relationship across space and lagged time between cannabis and TPCIR which was robust to adjustment, supported by inverse probability weighting procedures and accompanied by high e-Values making confounding unlikely and establishing the causal relationship. Cannabis-liberal jurisdictions were associated with higher rates of TPCIR and a faster rate of TPCIR increase. Data inform the broader general consideration of cannabinoid-induced genotoxicity. Read

Trends in cannabis view and use among American adults: Intersections with alcohol consumption, 2002-2018

1/30/21--This study aims to examine trends in cannabis views and use among US adults who are alcohol abstainers, non-binge drinkers, and binge drinkers. Findings indicate that cannabis disapproval has decreased and cannabis use increased among alcohol abstainers, non-binge drinkers, and binge drinkers between 2002 and 2018. The impact of cannabis disapproval on use attenuated during the study period among drinkers but not among abstainers, suggesting that the effect of anti-cannabis attitudes may be weakening among those most likely to use cannabis. Read

Intelligent quotient decline following or dependent cannabis in youth: a systematic review and meta-analysis of longitudinal studies

1/30/21--This systematic review and meta-analysis found a significant effect for the association between frequent or dependent cannabis use in youth and IQ change. Read

A comprehensive review of cannabis potency in the USA in the last decade

1/30/21--This report examines the concentration of seven major cannabinoids including Δ9-THC and CBD in illicit herbal cannabis products seized by the Drug enforcement Administration (DEA) over the last ten years in the USA. Results indicate that an overall increase in potency of illicit cannabis going from approximately 10% in 2009 to approximately 14% in 2019. Read

Cannabis use disorder and post-traumatic stress disorder: The prevalence of comorbidity in veterans of recent conflicts

1/30/21--This study analyzed data from the Veterans Affairs Corporate Data Warehouse (2010-2016) for returning war veterans who were diagnosed with CUD (N = 46,268). The findings highlight that the majority of returning war veterans with CUD are highly complex and substantiate the need for urgent, comprehensive care for veterans with co-occurring CUD and PTSD, including integrated and transdiagnostic treatment approaches. Read

Examining associations between licensed and unlicensed outlet density and cannabis outcomes from preopening to postopening of recreational cannabis outlets

1/29/21--This study expands beyond studies of outlet prevalence to find that, after controlling for outcomes 1 year prior, licensed and unlicensed outlets were associated with young adults' cannabis outcomes. The current study is among the first to find associations between cannabis use outcomes and density of cannabis outlets among young adults using data from two time points: preopening and postopening of recreational cannabis retailers. Read

Young-adult compared to adolescent onset of regular cannabis use: A 20-year prospective cohort study of later consequences

1/26/21--This paper compares consequences of cannabis use initiated after high school with those of cannabis initiation in adolescence, with estimates of the proportion of adverse consequences accounted for by adult-onset and adolescent-onset cannabis users. Read

NIH study suggests using cannabis while trying to conceive may reduce pregnancy chances

1/11/21--Women who use marijuana could have a more difficult time conceiving a child than women who do not use marijuana, suggests a study by researchers at the National Institutes of Health. Marijuana use among the women’s partners — which could have influenced conception rates — was not studied. The researchers were led by Sunni L. Mumford, Ph.D., of the Epidemiology Branch in NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development. The study appears in Human Reproduction. Read

Examining associations between licensed and unlicensed outlet density and cannabis outcomes from preopening to postopening of recreational cannabis outlets

1/15/21--This study expands beyond studies of outlet prevalence to find that, after controlling for outcomes 1 year prior, licensed and unlicensed outlets were associated with young adults' cannabis outcomes. The current study is among the first to find associations between cannabis use outcomes and density of cannabis outlets among young adults using data from two time points: preopening and postopening of recreational cannabis retailers. Findings can inform policies around the density and placement of cannabis outlets. Read

Comorbid cannabis use disorder with major depression and generalized anxiety disorder

12/16/20--This review confirms the evidence of high prevalence and a 3-fold comorbid association between CUD with MD and CUD with GAD. Implementation of evidence-based policy interventions with effective, integrated management of comorbid CUDs with psychiatric disorders may contribute to positive patient outcomes. Read

Cannabis use, cannabis use disorder, and comorbid psychiatric illness: A narrative review

12/23/20--According to this narrative review designed to provide a concise overview of the literature on the comorbidity of cannabis use and cannabis use disorder (CUD) with other substance use and psychiatric disorders, empirical evidence shows that cannabis use is associated both with CUD and comorbid psychiatric illness -- although the general population in the United States increasingly perceives cannabis to be a harmless substance. Read

A within-person comparison of the subjective effects of higher vs. lower-potency cannabis

8/19/20--According to a study published by the National Center for Biotechnology Information comparing the subjective effects of concentrates and marijuana, the main difference in the subjective effects of marijuana and concentrates is in terms of their positive effects, with marijuana producing greater positive effects than concentrates. Negative effects of marijuana and concentrates were small, suggesting that extreme negative effects are unlikely for regular cannabis users. Read

A Systematic Review of Minor Phytocannabinoids with Promising Neuroprotective Potential

7/1/20--Embase and Pubmed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, aside from cannabidiol and Δ9 -tetrahydrocannabinol, including Δ9 -tetrahydrocannabinolic acid (Δ9 -THCA), Δ9 -tetrahydrocannabivarin (Δ9 -THCV), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabichromevarin (CBCV), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabigerivarin (CBGV), cannabigerovarinic acid (CBGVA), cannabichromevarinic acid (CBCVA) cannabidivarinic acid (CBDVA) and cannabinol (CBN). Read

What is the Prevalence and Risk of Cannabis Use Disorders Among People Who Use Cannabis?

5/20/20--A systematic review was conducted of epidemiological cross-sectional and longitudinal studies on the prevalence and risks of a cannabis use disorder (CUD) among cannabis users. Study results indicate that cannabis users need to be informed about the risks of developing CUDs and the higher risks among those who initiate early and use frequently during adolescence. However, future studies are needed to examine how changes in cannabis policies may affect the risks of CUDs in the population. Read

Acute effects of cannabinoids on symptoms of Obsessive-Compulsive Disorder: A human laboratory study

5/7/20--This is the first placebo-controlled investigation of cannabis in adults with Obsessive-Compulsive Disorder (OCD). The data suggest that smoked cannabis, whether containing primarily THC or CBD, has little acute impact on OCD symptoms and yields smaller reductions in anxiety compared to placebo. Read

Cannabis (marijuana) and cannabinoids: What you need to know

12/5/19--People often use the words “cannabis” and “marijuana” interchangeably, but they don’t mean exactly the same thing. As reported in a fact sheet produced by the NIH - National Center for Complementary and Integrative Health, the word “cannabis” refers to all products derived from the plant Cannabis sativa. Whereas, the word “marijuana” refers to parts of or products from the plant Cannabis sativa that contain substantial amounts of tetrahydrocannabinol (THC). Read

ABCD study completes enrollment, announces opportunities for scientific engagement

12/3/18--The National Institutes of Health announced today that enrollment for the Adolescent Brain Cognitive Development (ABCD) Study is now complete and, in early 2019, scientists will have access to baseline data from all ABCD Study participants. Read

NIH’s 2017 Monitoring the Future survey shows both vaping and marijuana are more popular than traditional cigarettes or pain reliever misuse

12/14/17--Findings from the 2017 Monitoring the Future (MTF) survey of eighth, 10th, and 12th graders in schools nationwide indicates that nearly 1 in 3 students in 12th grade report past year use of some kind of vaping device, raising concerns about the impact on their health. The survey also suggests that use of hookahs and regular cigarettes is declining. Read

Criminal Justice

5/4/17--Scientific research since the mid-1970s shows that treatment can help many in the criminal justice system who use drugs change their attitudes, beliefs, and behaviors toward drug use; avoid relapse; and successfully remove themselves from a life of substance use and crime. Treatment can be effective, whether voluntary or ordered by the court. Once in a treatment program, even those who are not motivated to change at first can eventually become engaged in a continuing treatment process. Read